Piezo1Magnetogeneticsmechanical
benefit of MMG(Mageneto-mechanical-genetics)
- fast and reversible ion channel gating (almost tens of milliseconds) without any tissue heating
Problem of MMG, not enough force torque
the way they solved it is by
Cre-loxP recombinase system26,27,28 for a deterministic expression of piezo-type mechanosensitive ion channel component 1
each Piezo1 is linked to a magnetic nanoparticle and has 2 pN of torque